Dorsal root ganglion receptor subtype P2X3R mediates postoperative-hyperalgesic priming in mice

Author: Si-Jia ZHEN ¹ ; Bei ZHAO ¹ ; Bo-Xi ZHENG ¹ ; Shu-Xin TIAN ¹ ; Ting XU ¹ ; Ming-Hui WU ¹ ; Jun-Fan FANG ¹ ; Jun-Ying DU ¹ ; Chi XU ¹ ; Jian-Qiao FANG ¹ ; Yi LIANG ¹ ; Jie ZHOU ² ; Jian-Qiao FANG ² ; Yi LIANG ²
Author Information

1. Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Dept of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University
2. Dept of Acupuncture and Moxibustion, the Third Affiliated Hospital of Zhejiang Chinese Medical University
Publication Type:Journal Article
Keywords: dorsal root ganglia; P2X3R; P2X7R; postoperative-hyperalgesic priming; purinocep-tors; spinal cord dorsal horn
From: Chinese Pharmacological Bulletin 2023;39(7):1282-1288
CountryChina
Language:Chinese
Abstract: Aim To investigate the differences in the role of different purinergic receptor subtypes at different sites in postoperative-hyperalgesic priming in mice. Methods A postoperative-hyperalgesic priming model was constructed by injecting PGE