The inhibitory effect of Averrhoa carambola DMDD on high glucose-induced endoplasmic reticulum stress IRE1α pathway and inflammation in renal tubular epithelial cell HK-2

Author: Yu-Xiang WANG ¹ ; Jing-Xiao XIE ¹ ; Xiao-Ping ZHANG ¹ ; Chuan-Hao PANG ¹ ; Lu WANG ¹ ; Qiu-Yan CHEN ¹ ; Lin-Qian CHEN ¹ ; Ren-Bin HUANG ¹ ; Xiao-Jie WEI ²
Author Information

1. Pharmaceutical College, Guangxi Medical University, Guangxi University of Traditional Chinese Medicine
2. School of Basic Medine, Guangxi University of Traditional Chinese Medicine
Publication Type:Journal Article
Keywords: 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione; apoptosis; diabetic nephropathy; endoplasmic reticulum stress; IRE1 pathway; renal tubular epithe¬lial cells
From: Chinese Pharmacological Bulletin 2023;39(7):1270-1275
CountryChina
Language:Chinese
Abstract: Aim To investigate the inhibition effect of 2-dodecyl-6-methoxycyclohexa-2, 5-diene-l, 4-dione ( DMDD) on renal tubular epithelial cell HK-2 endo¬plasmic reticulum stress and inflammatory responses induced by high glucose. Methods HK-2 cells were cultured in vitro and divided into normal group, high glucose group, endoplasmic reticulum stress inhibitor 4-PBA group (5 mmoL • L ) , DMDD high, medium and low dose groups (8,4,2 μmol • L