Effect of FKBP38 protein on endometrial precancerous lesions and mechanism
- Author:
Yun-Jing YAN
1
;
Yun-Ping MU
1
;
Shuai WANG
1
;
Zi-Jian ZHAO
1
;
Fang-Hong LI
1
Author Information
- Publication Type:Journal Article
- Keywords: conditional knock out; Cre/loxP recombinase system; endometrial cancer; FKBP38; mTOR; transgenic mouse
- From: Chinese Pharmacological Bulletin 2023;39(7):1320-1324
- CountryChina
- Language:Chinese
- Abstract: Aim To build the model of the gene FKBP38(FK506 binding protein 38)conditional knock out in uterus and then investigate the effect on endometrial precancerous lesions and the underlying mechanism.Methods Transgenic mice whose FKBP38 gene was flanked with loxP were constructed by embryo microinjection. The conditional knockout of FKBP38 was obtained by breeding mice harboring two loxP sites in FKBP38(FKBP38
