Role and mechanism of glucagon-like peptide-1 in depression

Author: Le ZHANG ¹ ; Yu-Xuan CHEN ¹ ; Ning-Ning GUO ¹ ; Le ZHANG ² ; Xian-Wen ZHANG ²
Author Information

1. School of Mental Health, Jining Medical University
2. Medical School, Kunming University of Science and Technology
Publication Type:Journal Article
Keywords: depression; glucagon-like peptide-1; gut-brain axis; neuroinflammation; neurotrophic factor; oxidative stress
From: Chinese Pharmacological Bulletin 2023;39(7):1210-1212
CountryChina
Language:Chinese
Abstract: Glucagon-like peptide-1 (GLP-1) is a major hormone of incretin hormone and gut-brain axis, which is related to the control of energy homeostasis and the occurrence of obesity. In addition to suppressing appetite, GLP-1 has neuroprotective effects by acting on areas of the brain involved in stress response and mood regulation. Depression is a common mental disease, and GLP-1 is closely related to depression. This article reviews the role and mechanism of GLP-1 in depression.