Study on ameliorative effect of IDHP on excessive fat accumulation in hepatocytes

Author: Jian DONG ¹ ; Yu-Chuan ZHANG ¹ ; Qiang SU ¹ ; Na SUN ¹ ; Jian DONG ² ; Yu-Chuan ZHANG ² ; Qiang SU ² ; Ya-Jun BAI ³ ; Xiao-Hui ZHENG ³ ; Na SUN ⁴ ; Yan CHENG ⁵
Author Information

1. Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University
2. College of Life Science and Engineering, Northwest Minzu University
3. The College of Life Sciences, Northwest University
4. Key Lab of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University
5. Experimental Center of Northwest, Minzu University
Publication Type:Journal Article
Keywords: hepatocyte steatosis; IDHP; mitochondrial function; mitochondrial membrane potential; non-alcoholic fatty liver disease; PAOA
From: Chinese Pharmacological Bulletin 2023;39(8):1541-1547
CountryChina
Language:Chinese
Abstract: Aim To explore whether isopropyl3-(3, 4-dihydroxyphenyl) -2-hydroxypropanoate (IDHP) could inhibit fat accumulation in liver cells by improving mitochondrial function, and alleviate the symptom of excessive fat accumulation in patients with NAFLD. Methods Cell steatosis model was established by inducing hepatocyte fat accumulation using palmitic acid and oleic acid (PA: OA molar ratio =1