Rho A/ROCK signaling pathway involved in hyper responsiveness to aortic contraction in mice with type 2 diabetes
- Author:
Shu-Zhen CHEN
1
;
Yan-Xiang ZHENG
1
;
Xiao-Yue QIN
1
;
Chun-Yu DENG
1
;
Shu-Zhen CHEN
2
;
Yong-Jiang CAI
2
;
Yan-Xiang ZHENG
2
;
Xiao-Yue QIN
2
;
Su-Juan KUANG
2
;
Hui YANG
2
;
Fang RAO
2
;
Chun-Yu DENG
2
;
Yong-Jiang CAI
3
;
Chun-Yu DENG
3
Author Information
- Publication Type:Journal Article
- Keywords: aorta; L-type calcium channel; RhoA kinase; SOCC; type 2 diabetes; vasoconstriction
- From: Chinese Pharmacological Bulletin 2023;39(8):1484-1492
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the mechanism of RhoA/ROCK signaling pathway in abnormal aortic contractility in type 2 diabetes (T2DM) mice. Methods The experiment was divided into two groups, the control group (db/m mice) and the model group (db/db mice). Changes of the response to different methods were measured in aorta rings using a Multi Myograph System. At the same time, the protein expression changes of aortic smooth muscle contraction signaling pathway in mice were determined by Western method. Results Compared with the control group, the blood glucose and body weight levels of the mice in the T2DM group significantly increased, and the cardiac function was abnormal (P <0. 01). The contractile response of the aorta of the diabetic mice induced by the contractile agents Phe, 5-HT and CaCl
