Study on antidepressant effects of Nrf2/HO-l of volatile oil from Chai Dang Bo drug-group on OB model rats and its mechanism
- Author:
Jing-Wen HU
1
;
Zhi-Qiang XIE
1
;
Jiu-Seng ZENG
1
;
Tian-Tian QIN
1
;
Hong-Xiao XIE
1
;
Rong LIU
1
;
Nan ZENG
1
;
Nan ZENG
2
Author Information
- Publication Type:Journal Article
- Keywords: Chai Dang Bo drug-group; GSH; Nrf2/HO-l; olfactory bulbectomy; SOD; volatile oil
- From: Chinese Pharmacological Bulletin 2023;39(8):1507-1514
- CountryChina
- Language:Chinese
- Abstract: Aim To confirm the antidepressant effect of the volatile oil part of the disassembled prescription drugs (Chai Hu, Dang Gui and Bo He, referred to as CDB) from Xiaoyao Powder and investigate its mechanism via Nrf2/H0-1 signaling pathway on OB model rats. Methods GC-MS analysis of the main components of volatile oil part of CDB was performed. The rats were randomly divided into sham operation group, model group, fluoxetine hydrochloride group (FLX, 10 mg • kg
