Determination of content of matricin extracted from Cichorium glandulosum Boiss et Huet with n-butanol and its protective effect on hepatic fibrosis in rats

Author: Lm-Jie SU ¹ ; Bin MA ¹ ; Dong-Mei QIN ¹ ; Bo LYU ² ; Heng-Lei LUO ³ ; Wei ZHANG ³ ; Heng-Lei LUO ⁴ ; Wei ZHANG ⁴
Author Information

1. Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmacy, Shihezi University
2. The First Affiliated Hospital of School of Medicine, Shihezi University
3. Xinjiang Quanan Pharmaceutical Co., Ltd.
4. Xinjiang Key Laboratory for Research of Licorice and Products
Publication Type:Journal Article
Keywords: Cichorium glandulosum Boiss. et Huet; hepatic fibrosis; HPLC; matricin; N-butanol extraction site; TGF-β
From: Chinese Pharmacological Bulletin 2023;39(9):1731-1739
CountryChina
Language:Chinese
Abstract: Aim To investigate the effects of Cichorium glandulosum N-butanol extraction site (C G E) on hepatic fibrosis (H F) in SD rats and to determine the content of the main effective component matricin. Methods HPLC method was used to determine the content of matricin in CGE. The SD rats were randomly divided into control group, model group, CGE low-dose groups, medium-dose and high-dose, and curcumin group. In addition to control group rats' back subcutaneous injection (s c) normal saline, rats in the other groups were treated with body weight sc 40 % CC1