Effect of corilagin on cholesterol metabolism in macrophages and its mechanism

Author: Xin DENG ¹ ; Da MENG ¹ ; Jing-Yi WU ¹ ; Bing-Tong JIANG ¹ ; Ya-Qiong ZHANG ¹ ; Yi ZHAO ¹ ; Feng HUANG ¹ ; Yan-Yun CHE ¹ ; Yi-Yang YANG ²
Author Information

1. College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine
2. School of Environmented Science and Engineering, Taiyuan Institute of Technology
Publication Type:Journal Article
Keywords: atherosclerosis; cholesterol metabolism; corilagin; gene expression; macrophage; protein expression
From: Chinese Pharmacological Bulletin 2023;39(9):1696-1704
CountryChina
Language:Chinese
Abstract: Aim To elucidate the effect of corilagin (Cor) on cholesterol metabolism in macrophages and the underlying mechanism. Methods Molecular docking was applied to predict the protein target of Cor on cellular cholesterol metabolism. The RAW264.7 macrophage foam model induced by 80 mg • L