Mechanism of neuronal death in ischemic stroke

Author: Man-Man WANG ¹ ; Xue-Qin FU ¹ ; Xu-Huan ZOU ¹ ; Wei-Wei WANG ¹ ; Yong ZHANG ² ; Bao-Qi WANG ³ ; Rui LAN ³
Author Information

1. Fisrt Clinical Medical College, Henan University of Chinese Medicine
2. Dept of Traditional Chinese Medicine, The Third Affiliated Hospital of Zhengzhou University
3. Dept of Encephalopachy, The First Affiliated Hospital of Henan University of Chinese Medicine
Publication Type:Journal Article
Keywords: apoptosis; autophagy; ferroptosis; ischemic stroke; mechanism; neuron; potential therapeutic targets
From: Chinese Pharmacological Bulletin 2023;39(9):1627-1632
CountryChina
Language:Chinese
Abstract: Stroke is the second leading cause of death in the world, of which about 60 % - 80 % are ischemic stroke. Ischemic stroke will inevitably cause the damage of neurons in the core area. With the increase of ischemic time, other neurons in the ischemic penumbra will also die due to the loss of " signal connection", and further lead to body dysfunction. In view of the complexity of neuronal death mechanism after ischemic stroke, understanding the action principle of death mechanism can better save ischemic penumbra neurons. This review mainly expounds several main mechanisms and potential therapeutic targets of neuronal death after ischemic stroke, so as to provide basis and help for the improvement of action mechanism research and drug development.