Effect of Clkl gene on level of Aβ-induced autophagy in Alzheimer's disease

Author: Wen-Ying SI ¹ ; Xiao-Jing SUN ¹ ; Xiao-Hua DONG ¹ ; Xian-Yong MENG ² ; Yu-Qing HOU ²
Author Information

1. Dept of Pharmacy, Hebei North University, Hebei Key Laboratory of Neuropharmacology
2. The First Affiliated Hospital of Hebei North University
Publication Type:Journal Article
Keywords: Alzheimer's disease; amyloid βprotein; autophagy; Clkl; HIF-lα; PI3K/AKT/mTOR
From: Chinese Pharmacological Bulletin 2023;39(9):1662-1668
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of siRNA transfection of silencing Clkl gene on autophagy levels in AD model cells. Methods The Clkl gene was silted using siRNA transfection techniques. MTT was used to observe the effects of Aβ