GLPS improves EAE demyelination through inhibition of TLR4/NF-KB pathway

Author: Yan-Qing LI ¹ ; Qing WANG ¹ ; Zhi-Chao YANG ¹ ; Li-Juan SONG ¹ ; Jian-Chun LIU ¹ ; Cun-Gen MA ¹ ; Han-Bin WANG ² ; Li-Zhi YANG ² ; Bao-Guo XIAO ³
Author Information

1. The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Research Center of Neurobiology, Shanxi University of Chinese Medicine
2. Shanxi Guorun Pharmaceutical Co., Ltd
3. State Key Laboratory of Neurobiology, Dept of Neurology, Huashan Hospital, Fudan University
Publication Type:Journal Article
Keywords: anti-inflammation; demyelination; experimental autoimmune encephalomyelitis; linopolysaccharide; neuroprotection; TLR4/NF-KB pathway
From: Chinese Pharmacological Bulletin 2023;39(10):1914-1920
CountryChina
Language:Chinese
Abstract: Aim To explore the protective effects of ganoderma lucidum polysaccharides (GLPS) on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS) and the underlying mechanism. Methods Thirty C57BL/6 mice were randomly divided into three groups: normal control group, EAE model group and GLPS group (5 mg • kg