Angelica sinensis polysaccharide promotes stress erythropoiesis in mice caused by 5-FU
- Author:
Bi-Yao WANG
1
;
Han-Xian-Zhi XIAO
1
;
Yi-Lin NIU
1
;
Nian-Ci SUN
1
;
Zi-Ling WANG
1
;
Ya-Ping WANG
1
;
Lu WANG
1
;
Bi-Yao WANG
2
;
Han-Xian-Zhi XIAO
2
;
Yi-Lin NIU
2
;
Nian-Ci SUN
2
;
Zi-Ling WANG
2
;
Ya-Ping WANG
2
;
Lu WANG
2
Author Information
- Publication Type:Journal Article
- Keywords: 5-flu-orouracil; angelica sinensis polysaccharides; burst forming unit-ery-throid; erythroblast islands; macropahges; stress erythropoiesis
- From: Chinese Pharmacological Bulletin 2023;39(10):1949-1956
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the effects of angelica sinensis polysaccharide (ASP) antagonizing 5-fluorou-raeil (5-FU) on spleen stress erythropoiesis in mice and its related mechanism. Methods C57BL/6J mice aged 6-8 weeks were randomly divided into control group, ASP group, 5-FU group and ASP + 5-FU group. The mouse body weight during the modeling pe-riod was recorded, and peripheral blood routine and the number of mononuclear cells in the bone marrow of femur were measured. Histopathology of spleen was de-tected, also the index and cellularity of spleen were analyzed. BFU-E of spleen mononuclear cells was counted. The number of F4/80
