Tanshinone IIA promotes reverse cholesterol transport to improve atherosclerosis
- Author:
Yi-Fan ZHANG
1
;
Min DU
1
;
Jia-Rou WANG
1
;
Si-Jin LI
1
;
Xiao-Teng FENG
1
;
Ping LIU
1
;
Xiang-Hui HAN
2
Author Information
- Publication Type:Journal Article
- Keywords: atherosclerosis; foam cells; lipid metabolism; macrophage; reverse cholesterol transport; tanshinone II A
- From: Chinese Pharmacological Bulletin 2023;39(10):1835-1839
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the effect of tanshinone II A (Tan II A) on reverse cholesterol transport in atherosclerosis model mice and RAW264. 7 cells and the underlying mechanism. Methods Thirty-two male LDLR -/- mice were randomly divided into four groups. These mice were fed with normal diet or high fat diet for 12 weeks. The control group and model group were given normal saline. Tan II A group and atorvastatin group were given Tan II A solution and atorvastatin solution for 12 weeks. RAW264. 7 cells were induced with oxidized low-density lipoprotein (ox-LDL) 100 mg • L-
