Advances in involvement of pericyte in tumour microenvironment in tumour metastasis

Teng Zhang; Meng-yao Song; Cheng Qian; Yang Zhao; Yin LU; Yang Zhao; Yin LU; Yin LU

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Advances in involvement of pericyte in tumour microenvironment in tumour metastasis

Author: Teng ZHANG ¹ ; Meng-Yao SONG ¹ ; Cheng QIAN ¹ ; Yang ZHAO ¹ ; Yin LU ¹ ; Yang ZHAO ² ; Yin LU ³ ; Yin LU ⁴
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1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy
2. Dept of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine
3. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumour
4. Jiangsu International Cooperative Joint Laboratory of Traditional Chinese Medicine and Regenerative Medicine Research, Nanjing University of Chinese Medicine
Publication Type:Journal Article
Keywords: angiogenesis; pericyte; pericyte heterogeneity; pre-metastatic niche; tumor; tumor microenvironment
From: Chinese Pharmacological Bulletin 2023;39(10):1819-1823
CountryChina
Language:Chinese
Abstract: Pericytes are essential components of vessel mural cells that function to regulate blood flow, clear or phagocytose debris, and are contractile cells enwrapping capillaries throughout the body. It controls vascular permeability and is involved in the development of blood vessels and is an important regulator and potential drug target of angiogenesis and vascular function. Pericytes are also thought to play a key role in the tumor microenvironment, especially during tumor growth and distal metastasis. Therefore,in this review we discuss the relationship between pericytes involved in tumor angiogenesis and tumor metastasis, as well as the use of targeted pericytes to treat tumors,with a view to providing a basis for subsequent studies.