Ginsenoside Rgl inhibits neuronal ferroptosis caused by ischemic stroke through activating of Nrf2/xCT/GPX4 axis

Author: Kai-Chao HU ¹ ; Jia-Qi HE ¹ ; Shi-Feng CHU ¹ ; Zhao ZHANG ¹ ; Nai-Hong CHEN ¹ ; Kai-Chao HU ² ; Yan GAO ² ; Jia-Qi HE ² ; Nai-Hong CHEN ²
Author Information

1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicine, Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences
2. School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine
Publication Type:Journal Article
Keywords: ferroptosis; ginsenoside Rgl; GPX4; ischemic stroke; Nrf2; xCT
From: Chinese Pharmacological Bulletin 2023;39(10):1905-1913
CountryChina
Language:Chinese
Abstract: Aim To study the inhibitory effect of ginsenoside Rgl on neuronal ferroptosis after ischemic stroke and its mechanism. Methods A model of oxygen glucose deprivation/reoxygenation (OGD/R) was established in HT22 cells, and the effect of Rgl on the viability of HT22 cells after OGD/R injury was detected by CCK-8. The effect of Rgl on ferroptosis in HT22 cells after OGD/R injury was detected by the test of ferroptosis markers GSH/GSSG, SOD, MDA, and Fe