Research progress of HDACs and associated inhibitors on regulation of acute lung injury
- Author:
Kai LAI
1
;
Ming-Lang GAO
1
;
Ning LI
1
;
Qing GENG
1
Author Information
- Publication Type:Journal Article
- Keywords: acute lung injury; alveolar fluid clearance; endothelial permeability; histone deacetylase inhibitors; histone deacetylases; inflammation; lung tissue repair- ment; oxidative stresses
- From: Chinese Pharmacological Bulletin 2023;39(12):2216-2221
- CountryChina
- Language:Chinese
- Abstract: Acute lung injury ( ALI) and its most extreme form a-cute respiratory distress syndrome ( ARDS) are lung diseases with high morbidity and mortality. There is no effective therapeutic intervention until now for its complicated pathophysiologi-cal processes and sophisticated regulatory mechanism. Histone deacetylases (HDACs) are a family of proteins with deacetylase activity. Studies have shown that HDACs are involved in the pathophysiological processes of ALI/ARDS, including inflammatory responses,endothelial permeability,oxidative stresses,alveolar fluid clearance and lung tissue repairment. Simultaneously, the use of HDACs inhibitors (HDACIs) can interfere with ALI/ ARDS progression. In this review we describe and summarize the pathophysiological processes and the underlying mechanisms in ALI/ARDS regulated by HDACs and HDACIs in detail, in order to provide the basis for the clinical application of HDACs-targe- ted agents and indicate directions for future study.
