Oxymatrine regulates autophagy through AMPK/mTOR pathway to inhibit OGD/R-induced damage in astrocytes

Author: Ming-Yu CUI ¹ ; Jin-Ying LU ¹ ; Lu YU ¹ ; Yu-Tong WANG ¹ ; Jiang BIAN ¹ ; Gao WANG ¹ ; Xin-Xia YANG ¹ ; Jing YANG ¹
Author Information

1. Dept of Biochemistry and Molecular Biology, Bade Medical College, Jinzhou Medical University
Publication Type:Journal Article
Keywords: AMPK/mTOR signaling pathway; astrocytes; autophagy; OGD/R; oxidative stress; oxymatrine
From: Chinese Pharmacological Bulletin 2023;39(12):2331-2338
CountryChina
Language:Chinese
Abstract: Aim To investigate the role of autophagy regulated by the AMPK/mTOR pathway in the prevention of oxygen-glucose deprivation/reperfusion injury ( OGD/R) in astrocytes using oxymatrine ( OMT ) . Methods The isolated and purified astrocytes ( AS) were randomly divided into control group ( CON group), OGD/R group and OGD/R + OMT group (0. 1, 0. 2, 0. 4 mmol · L