The regulatory mechanism of physiological sleep-wake

Author: Wei-Jie LU ¹ ; Kai LIU ¹ ; Xin-Ke ZHAO ¹ ; Qian-Rong LI ¹ ; Ying-Dong LI ¹ ; Guo-Tai WU ²
Author Information

1. College of Integrated Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine
2. College of Pharmacy, Gansu University of Chinese Medicine
Publication Type:Journal Article
Keywords: hypnogen; regulatory mechanism; sleep awakening; sleep circadian system; sleep homeostasis system; suprachiasmatic nucleus
From: Chinese Pharmacological Bulletin 2024;40(3):421-426
CountryChina
Language:Chinese
Abstract: This paper explains the mechanism of the mutual switching between physiological sleep and wakefulness from the aspects of the sleep circadian system and the sleep homeostasis system. In the circadian rhythm system, with the suprachiasmatic nucleus as the core, the anatomical connections between the suprachiasmatic nucleusand various systems that affect sleep are summarized, starting from the suprachiasmatic nucleus, passing through the four pathways of the melatonin system, namely, subventricular area of the hypothalamus, the ventrolateral nucleus of the preoptic area, orexin neurons, and melatonin, then the related mechanisms of their regulation of sleep and wakefulness are expounded. In the sleep homeostasis system, with adenosine and prostaglandin D2 as targets, the role of hypnogen in sleep arousal mechanisms in regulation is also expounded.