The neuroprotective effects of Haikun Shenxi capsule medicated serum on N2a/APP695 cells based on PINKl-Parkin mitophagy pathway

Author: Yan-Hua SUN ¹ ; Jing JI ¹ ; Jiao PENG ¹ ; Shan HE ¹ ; Shan HE ² ; Xian-Jun FU ²
Author Information

1. College of Pharmacy, Shandong University of Traditional Chinese Medicine
2. Marine Traditional Chinese Medicine Research Center, Shandong University Key Laboratory of Marine Traditional Chinese Medicine, Shandong Traditional Chinese Medicine Omics Engineering Technology Research Center, Shandong University of Traditional Chinese Medicine
Publication Type:Journal Article
Keywords: Haikun Shenxi medicated serum; Key words : Alzheimer's disease; mitophagy; N2a/App695 cells; PINKl-Parkin; removing turbidity and detoxifying
From: Chinese Pharmacological Bulletin 2024;40(3):461-468
CountryChina
Language:Chinese
Abstract: Aim To research the neuroprotective effect of Haikun Shenxi (HKSX) medicated serum on N2a/ App695 cells and the underlying mechanism. Methods HKSX medicated serum was prepared and carbohydrate components in it was analyzed using high performance thin layer chromatography (HPTLC) . N2a/ App695 cells were intervened with HKSX medicated serum, the cytotoxicity of HKSX medicated serum was measured by MTT; AP[_