Ligustilide delays senescence of auditory cortex in mice by inhibiting ferritinophagy

Author: Ying-Dong ZHOU ¹ ; Meng-Xian ZHANG ¹ ; Qing-Ling WANG ¹ ; Hao-Ran KANG ² ; Zhi-Cheng ZHANG ² ; Xiang-Dong GUO ² ; Qing-Lin WANG ³ ; Ya-Min LIU ⁴
Author Information

1. the First School of Clinical Medicine, Henan University of Chinese Medicine
2. Dept of Otolaryngological, the First Affiliated Hospital of Henan University of Chinese Medicine
3. Henan Medical College
4. College of Pharmacy, Henan University of Chinese Medicine
Publication Type:Journal Article
Keywords: auditory cortex; auditory threshold; ferritinophagy; ferroptosis; Key w o r d s: central presbycusis; ligustilide
From: Chinese Pharmacological Bulletin 2024;40(3):455-461
CountryChina
Language:Chinese
Abstract: Aim To investigate the mechanism of ligu aged 2 months of the same strain were used as the constilide (LIG) in delaying the senescence of auditory trol (Ctrl) group. Auditory brainstem response test was cortex and treating central presbycusis. Methods used to detect the auditory threshold of mice before and Forty C57BL/6J mice aged 13 months were randomly di after treatment. Levels of serum MDA and activity of vided into ligustilide low-dose(L-LIG) group, ligustil serum SOD were detected to display the level of oxidative ide medium-dose (M-LIG) group, ligustilide high-dose stress. The pathological changes of auditory cortex were (H-LIG) group and aging (Age) group, and 10 mice observed by HE staining. Ferroptosis was observed by