Research progress of Parkin protein regulating mitochondrial homeostasis through ubiquitination in cardiovascular diseases
- Author:
Ke-Juan LI
1
;
Jian-Shu CHEN
1
;
Yi-Xin XIE
1
;
Jia-Le BU
1
;
Xiao-Wei ZHANG
1
;
Yong-Nan LI
2
Author Information
- Publication Type:Journal Article
- Keywords: coronary heart disease; heart failure; hypertension; mitochondrial dynamics; mitophagy; myocardiopathy; PINK1 / Parkin; ubiquitination
- From: Chinese Pharmacological Bulletin 2024;40(2):224-228
- CountryChina
- Language:Chinese
- Abstract: In addition to providing energy for cells, mitochondria also participate in calcium homeostasis, cell information transfer, cell apoptosis, cell growth and differentiation. Therefore, maintaining mitochondrial homeostasis is very crucial for the body to carry out normal life activities. Ubiquitination, a post-translational modification of proteins, is involved in various physiological and pathological processes of cells by regulating mitochondrial homeostasis. However, the mechanism by which ubiquitination regulates mitochondrial homeostasis has not been summarized, especially the effect of Parkin protein on cardiovascular diseases. In this paper, the specific mechanism of mitochondrial homeostasis regulated by ubiquitination of Parkin protein is discussed, and the influence of mitochondrial homeostasis imbalance on cardiovascular diseases is reviewed, with a view to providing potential therapeutic strategies for the clinical treatment of cardiovascular diseases.
