Inhibition of HSP70 release by geniposide improves angiogenesis in moist heat arthralgia spasm syndrome collagen induced arthritis rats

Author: Yin SHU ¹ ; Pei-Rong GAN ¹ ; Yan WANG ¹ ; Yan-Hong BU ¹ ; Hong WU ¹
Author Information

1. School of Pharmacy, Anhui University of Chinese Medicine, Key Lab of xin'An Medicine, Ministry of Education, Anhui Province Key Lab of Chinese Medicinal Formula
Publication Type:Journal Article
Keywords: angiogenesis; geniposide; heat stress; HSP70; human umbilical vein vascular endothelial cells; moist heat arthralgia spasm syndrome CIA rats
From: Chinese Pharmacological Bulletin 2024;40(2):324-334
CountryChina
Language:Chinese
Abstract: Aim To investigate the relation between the effect of geniposide (GE) in improving angiogenesis in arthralgia spasm syndrome collagen induced arthritis (CIA) rats and the modulation of heat shock proteins 70 (HSP70) release. Methods A CIA model was constructed by multiple intradermal injections of complete Freund's adjuvant (CFA) and an equal volume mixture of chicken type II collagen (CCII) into the dorsal and caudal root regions of rats, on the basis of which a rheumatic fever stimulus was given to build up a moist heat arthralgia spasm syndrome in CIA rats. After successful modeling, the groups were randomly grouped, and the administered groups were gavaged with GE (60, 120 mg · kg