Resveratrol inhibits autophagy and promotes apoptosis in uveal melanoma cells via miR-512-3P/DUSPl axis

Author: Zheng-Yang SUN ¹ ; Nan-Nan LIU ¹ ; Xue-Fei FAN ¹ ; Su-Huan CHEN ¹ ; Xiao-Yu CHEN ¹ ; Zheng-Yang SUN ² ; Wu-Qi CHEN ³ ; Guang-Yi CHEN ³ ; Yu-Bao SHAO ⁴ ; Xiao-Yu CHEN ⁴
Author Information

1. Dept of Histology and Embryology, Anhui Medical University
2. Dept of Ophthalmology, Hospital of University of Science and Technology of China
3. Dept of Clinical Medicine, Anhui Medical University
4. Experimental Center of Morphology, Anhui Medical University
Publication Type:Journal Article
Keywords: apoptosis; autophagy; DUSP1; miR-512-3P; resveratrol; uveal melanoma
From: Chinese Pharmacological Bulletin 2024;40(2):292-298
CountryChina
Language:Chinese
Abstract: Aim To investigate the regulatory role and mechanism of resveratrol in inhibiting autophagy and promoting apoptosis in choroidal melanoma cells. Methods Choroidal melanoma cells (MUM2B) were divided into control and experimental groups, and treated with different concentrations of resveratrol (0, 10, 20,40,60,80 μmol ·L