Advances in relationship between pyroptosis and pulmonary arterial hypertension and therapeutic drugs
- Author:
Qian YAN
1
;
Yang SUN
1
;
Jun-Peng LONG
1
;
Jiao YAO
1
;
Yu-Ting LIN
1
;
Song-Wei YANG
1
;
Yan-Tao YANG
1
;
Gang PEI
1
;
Qi-Di AI
1
;
Nai-Hong CHEN
1
;
Qian YAN
2
;
Yang SUN
2
;
Jun-Peng LONG
2
;
Jiao YAO
2
;
Yu-Ting LIN
2
;
Song-Wei YANG
2
;
Yan-Tao YANG
2
;
Gang PEI
2
;
Qi-Di AI
2
;
Nai-Hong CHEN
2
;
Sha-Sha LIU
3
;
Nai-Hong CHEN
4
Author Information
- Publication Type:Journal Article
- Keywords: inflammasome; pathogenesis; pulmonary arterial hypertension; pulmonary hypertension; pyroptosis; therapeutic drugs
- From: Chinese Pharmacological Bulletin 2024;40(1):25-30
- CountryChina
- Language:Chinese
- Abstract: Pyroptosis is the programmed death of cells accompanied by an inflammatory response and is widely involved in the development of a variety of diseases, such as infectious diseases, cardiovascular diseases, and neurodegeneration. It has been shown that cellular scorching is involved in the pathogenesis of pulmonary arterial hypertension ( PAH) in cardiovascular diseases. Patients with PAH have perivascular inflammatory infiltrates in lungs, pulmonary vasculopathy exists in an extremely inflam-matory microenvironment, and pro-inflammatory factors in cellular scorching drive pulmonary vascular remodelling in PAH patients. This article reviews the role of cellular scorch in the pathogenesis of PAH and the related research on drugs for the treatment of PAH, with the aim of providing new ideas for clinical treatment of PAH.
