Curcumin plays an anti-osteoporosis role by inhibiting NF-κB signaling pathway to reduce oxidative stress damage to osteogenesis
- Author:
Tian-Tian XU
1
;
Hao-Ehun TIAN
2
;
Xin-Min YANG
2
;
Qi-Hua QI
2
;
Dong-Hua LUO
3
;
Chang-Gen WANG
4
Author Information
- Publication Type:Journal Article
- Keywords: bone formation; curcumin; mechanism of action; nuclear transcription factor-κB; osteoporosis; oxidative stress
- From: Chinese Pharmacological Bulletin 2024;40(1):46-54
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the mechanism of curcumin inhibition of oxidative stress on osteogenic differentiation and its dose-dependent anti-osteoporosis effect. Methods Cellular oxidative stress models were used, different concentrations of curcumin were added to determinethebone formation markers, and the potential signaling pathways involvedwere detected. Meanwhile, the mouse model of osteoporosis ( ovariecto- mized, 0VX) was used to confirm its effect against osteoporosis. Results In vitro experiments found that low concentrations of curcumin (1-10 μmol · L
