Research progress of neuronal injury mediated by microglial activation and depression

Author: Ying HE ¹ ; Man-Shu ZOU ¹ ; Yu-Hong WANG ¹ ; Yuan-Shan HAN ² ; Man-Shu ZOU ³ ; Yuan-Shan HAN ³ ; Yu-Hong WANG ³
Author Information

1. Science and Technology Innovation Center, Hunan University of Chinese Medicine
2. The First Affiliated Hospital of Hunan University of Chinese Medicine
3. Hunan Provincial Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of pepression
Publication Type:Journal Article
Keywords: depression; immune response; inflamma-tion; mechanism of action; microglia; neuron damage
From: Chinese Pharmacological Bulletin 2024;40(1):12-15
CountryChina
Language:Chinese
Abstract: Depression is a common neurological disorder with high incidence, high recurrence and high disability, but its pathogenesis is unclear. In recent years, the protective and attacking effects of glial cells on neurons have become the frontier of neurological disease research. Neuronal injury caused by abnormal activation of microglia (MG) plays an important role in the pathogenesis of depression. In this paper, through literature retrieval by GeenMedical and CNKI, the relevant pathways and key targets of MG activation in depression are summarized so as to provide a theoretical basis for further clinical research.