Effects of metabolites of eicosapentaenoic acid on promoting transdifferentiation of pancreatic OL cells into pancreatic β cells
- Author:
Chao-Feng XING
1
;
Min-Yi TANG
1
;
Qi-Hua XU
1
;
Shuai WANG
1
;
Zong-Meng ZHANG
1
;
Zi-Jian ZHAO
1
;
Yun-Pin MU
1
;
Fang-Hong LI
1
Author Information
- Publication Type:Journal Article
- Keywords: eicosapentaenoic acid; metabolites; pancreatic a cells; pancreatic β cells; trans- differentiation; type 1 diabetes mellitus
- From: Chinese Pharmacological Bulletin 2024;40(1):31-38
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the role of metabolites of eicosapentaenoic acid (EPA) in promoting the transdifferentiation of pancreatic α cells to β cells. Methods Male C57BL/6J mice were injected intraperitoneally with 60 mg/kg streptozocin (STZ) for five consecutive days to establish a type 1 diabetes (T1DM) mouse model. After two weeks, they were randomly divided into model groups and 97% EPA diet intervention group, 75% fish oil (50% EPA +25% DHA) diet intervention group, and random blood glucose was detected every week; after the model expired, the regeneration of pancreatic β cells in mouse pancreas was observed by immunofluorescence staining. The islets of mice (obtained by crossing GCG
