Research progress on bone metabolism and molecular mechanisms in accelerated aging SAMP6 mice

Author: Shao-Yong MA ¹ ; Meng YANG ¹ ; Jia-Jia WANG ¹ ; Ya-Jun YANG ¹
Author Information

1. Dept of Pharmacology, Guangdong Key Lab for Research and Development of Natural Drugs, Guangdong Medical University
Publication Type:Journal Article
Keywords: animal models; bone metabolism; functional molecules; senescence accelerated mouse prone 6; senile osteoporosis; Wnt/p-catenin signaling pathway
From: Chinese Pharmacological Bulletin 2024;40(1):16-19
CountryChina
Language:Chinese
Abstract: Senile osteoporosis (SOP) is a systemic bone disease characterized by increased susceptibility to fractures. The pathogenesis of SOP is complex and not well understood. Currently, the rapid aging model mouse, senescence accelerated mouse prone 6 (SAMP6), is an ideal model for studying the mechanisms of SOP development and exploring its prevention and treatment. This model exhibits characteristics including increased bone fragility, degradation of bone microstructure, loss of bone matrix, and abnormal metabolism and dysfunction of bone cells, faithfully replicating the process of SOP occurrence and progression at both macroscopic and microscopic levels.