Research progress in the route of administration and corresponding dosage form of triamcinolone acetonide
- VernacularTitle:曲安奈德给药途径及相应剂型的研究进展
- Author:
Tianjiao SHAO
1
,
2
;
Lili JIN
1
;
Shan WANG
2
;
Bohua YAN
2
;
Xinming HU
1
,
2
;
Jing GAO
2
Author Information
1. College of Pharmacy，Yanbian University，Jilin Yanji 133002，China
2. Institute of Pharmacology and Toxicology，Academy of Military Sciences，Academy of Military Sciences，Beijing 100850，China
- Publication Type:Journal Article
- Keywords:
triamcinolone acetonide;
route of administration;
dosage form;
injection administration;
mucosal administration
- From:
China Pharmacy
2024;35(7):896-900
- CountryChina
- Language:Chinese
-
Abstract:
As a glucocorticoid drug with wide clinical application， triamcinolone acetonide can be administered by multiple routes， such as eye， nose， joint cavity， and skin， for the treatment of various local diseases such as arthritis， macular edema， rhinitis， and urticaria. As a drug with extremely low solubility in water， the dose form of triamcinolone acetonide is closely correlated with administration route and site. The dosage form of triamcinolone acetonide administered via injection（including joint cavity injection， vitreous injection， suprachoroidal injection， intramuscular injection） is mainly suspension， and the representative drugs include Kenalog-40®， Zilretta®， Triesence®， Xipere®， etc.； the dosage forms of nasal mucosal administration are mostly sprays， and the representative drug is Nasacort®； the dosage forms of oral mucosal administration are mostly patches， ointments and creams， and the representative drug is Oracort®； the dosage forms for transdermal administration are mostly ointments， creams and lotions， and the representative drugs include Trianex®， Teva-Triacomb®， etc. At present， the research on dosage forms of triamcinolone acetonide by various administration routes mainly focuses on the construction of delivery carriers， the addition of cosolvents or the use of new delivery tools.
