Study on extraction technology of Sophora flavescens-Phellodendron chinense drug pair
- VernacularTitle:苦参-黄柏药对的提取工艺研究
- Author:
Yongmei GUAN
1
;
Ying TAO
1
;
Chengyu ZOU
1
;
Zhenzhong ZANG
1
;
Lihua CHEN
1
;
Lili LIU
1
;
Limei CHEN
1
,
2
;
Weifeng ZHU
1
Author Information
1. Key Laboratory of Modern Preparation of TCM，Ministry of Education，Jiangxi University of Chinese Medicine，Nanchang 330004，China
2. Research Department，the Affiliated Hospital of Jiangxi University of Chinese Medicine，Nanchang 330004，China
- Publication Type:Journal Article
- Keywords:
Sophora flavescens;
Phellodendron chinense;
drug pair;
Box-Behnken design;
response surface method
- From:
China Pharmacy
2024;35(7):793-800
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the extraction technology of Sophora flavescens-Phellodendron chinense drug pair and provide a reference for the development of new drugs for the treatment of anorectal diseases. METHODS Using the contents of total alkaloids of S. flavescens （matrine+oxymatrine）， berberine hydrochloride and total flavonoid， and extract yield as evaluation indicators， analytic hierarchy process-entropy weight method was used to calculate the weight coefficient of each indicator， and was combined with Box-Behnken design-response surface method to study the extraction technology of S. flavescens-P. chinense drug pair and verify it. RESULTS The optimal extraction technology of S. flavescens-P. chinense drug pair was immersed in 12-fold amount of 58% ethanol for 30 minutes and extracted twice， each time for 120 minutes. The relative error between the verification experimental results and the predicted value was 1.88%. CONCLUSIONS The obtained extraction technology is stable and feasible and can provide reference for the application of S. flavescens-P. chinense drug pair and development of new drugs.
