The accuracy of tumor size measurement and clinical T staging for resected lung cancer: Retrospective analysis of 1 880 patients
- VernacularTitle:经手术切除肺癌肿瘤大小测量和临床T分期准确性：1 880例患者的回顾性分析
- Author:
Kai ZHOU
1
;
Chaoqiang DENG
2
;
Yang ZHANG
2
Author Information
1. Department of Thoracic Surgery, Jiangdu People s Hospital of Yangzhou City Affilialed Yangzhou University, Yangzhou, 225200, Jiangsu, P. R. China
2. 2. Department of Thoracic Surgery, Cancer Center, Fudan University, Shanghai, 200032, P. R. China 3. State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, P. R. China 4. Institute of Thoracic Oncology, Fudan University, Shanghai, 200032, P. R. China 5. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China
- Publication Type:Journal Article
- Keywords:
Lung cancer;
tumor size;
staging;
treatment strategy
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2024;31(02):223-228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the correlation between radiological tumor size (RTS) and pathological tumor size (PTS), and to evaluate the accuracy of clinical T staging. Methods Data on patients who underwent complete resection between September 2018 and June 2019 were retrospectively collected. The correlation between RTS and PTS was analyzed by and we assessed the agreement between clinical and pathologic T staging. Results Finally, 1 880 patients were included. There were 778 males and 1 102 females at average age of 57±11 years. In the entire cohort, the RTS and PTS was 19.1±13.5 mm and 17.7±14.0 mm, respectively (P<0.001). The RTS and PTS showed a strong linear correlation with the Pearson’s correlation coefficient calculated as 0.897. The mean RTS was significantly larger than PTS (P<0.001) in tumors≤3 cm, but significantly smaller in tumors>4 cm. The overall concordance rate between clinical and pathological T staging was 65.6%. Clinical staging failed to detect T4 disease in 29.4% (5/17) of patients. Male patients and the presence of cavities within nodules were independent significant factors leading to inaccurate clinical T staging. Conclusions The correlation between the tumor sizes measured on thin-section computed tomography and pathologic specimens varies with the real tumor size. Methods and techniques for improving clinical T staging accuracy is in urgent need.
