Chorea Hyperglycemia Basal Ganglia Syndrome: A case report of a rare diabetes complication
- Author:
Cristina A. Dorado
1
;
Neshreen J. Kingking
1
;
Remirr Theodore P. Nolasco
1
;
Meliza Dadua-Ecal
2
;
Jay S. Fonte
3
Author Information
- Publication Type:Journal Article
- Keywords: Diabetic striatopathy; Chorea hyperglycemia basal ganglia
- MeSH: Movement Disorders; Diabetes Complications
- From: Philippine Journal of Internal Medicine 2024;62(1):326-330
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:We present a patient with long-standing uncontrolled type 2 diabetes mellitus (T2 DM) who developed
sudden onset of choreiform movement, which rapidly resolved after insulin therapy and haloperidol.
Case Description:A 53-year-old Filipino male, with T2DM and hypertension for more than 10 years, presented with sudden onset of hyperkinetic, involuntary, non-patterned, continuous movements of the left upper and lower extremities. Investigations revealed severe hyperglycemia without acidemia and ketonuria. Cranial computed tomography scan showed hyperdensity on the right caudate and lentiform nuclei. On cranial magnetic resonance imaging, there was T1- weighted hyperintense and T2 - weighted hypointense signal involving the right putamen, globus pallidus and caudate. Cranial magnetic resonance angiography showed stenosis on the cavernous segment of the right internal carotid artery (ICA), left ICA and middle cerebral artery (MCA) junction, the A1 segment of the left anterior communicating artery and proximal P2 segments of the bilateral posterior cerebral arteries. The patient was managed with a basal-bolus insulin regimen to control the blood glucose and haloperidol to manage the extrapyramidal symptoms. Consequently, there was complete resolution of the involuntary movements.
Conclusion:This case illustrates the importance of a systematic approach to movement disorders and early recognition of this rare diabetes complication known as chorea hyperglycemia basal ganglia syndrome or diabetic striatopathy. - Full text:12 2022-197 Case OK.pdf
