Impact of autonomic nerve function on motor function in patients with post-stroke depression
10.3969/j.issn.1006-9771.2024.02.013
- VernacularTitle:自主神经功能对卒中后抑郁患者运动功能的影响
- Author:
Minglan ZHANG
1
;
Lingling ZHANG
2
;
Lisha WANG
1
;
Li LIU
2
;
Run GAO
2
;
Jiang RAO
2
;
Wan LIU
2
;
Zi'an XIA
2
;
Chuanwen ZHANG
2
;
Xinxin CHENG
2
Author Information
1. Department of Electrocardiogram Room, the Affiliated Brain Hospital of Nanjing Medical University, NanJing, Jiangsu 210029, China
2. Department of Rehabilitation Medicine, the Affiliated Brain Hospital of Nanjing Medical University, NanJing, Jiangsu 210029, China
- Publication Type:Journal Article
- Keywords:
post-stroke depression;
heart rate variability;
autonomic nerve;
functional magnetic resonance imaging;
regional homogeneity
- From:
Chinese Journal of Rehabilitation Theory and Practice
2024;30(2):223-231
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the impact of autonomic nerve function on motor function in patients with post-stroke depression (PSD) from the perspective of regional homogeneity (ReHo). MethodsFrom January to December, 2020, a total of 60 inpatients and outpatients with cerebral infarction in the Affiliated Brain Hospital of Nanjing Medical University were divided into control group (n = 30) and PSD group (n = 30). Two groups were assessed using Fugl-Meyer Assessment (FMA), modified Barthel Index (MBI) and Hamilton Depression Scale (HAMD). Heart rate variability (HRV) was measured. Ten patients in each group were selected randomly to undergo resting state functional magnetic resonance imaging (rs-fMRI) to calculate ReHo. ResultsAll HRV indices were lower in PSD group than in the control group (|t| > 2.092, P < 0.05). In PSD group, FMA and MBI scores showed positive correlations with 24-hour standard deviation of normal-to-normal R-R intervals (SDNN), the root mean square of successive differences between normal heartbeats over 24 hours (RMSSD), the percentage of differences between adjacent normal R-R intervals over 24 hours that were greater than 50 ms (PNN50), total power (TP), very low frequency power (VLF) and low frequency power (LF) (r > 0.394, P < 0.05), and showed negative correlations with HAMD scores (|r| > 0.919, P < 0.001). HAMD scores in PSD group were negatively correlated with SDNN, RMSSD, PNN50, TP and VLF (|r| > 0.769, P < 0.001). Compared with the control group, the ReHo increased in PSD group in the right rectus gyrus (142 voxels, t = 6.575), the left medial and paracingulate gyri (204 voxels, t = 4.925) (GRF correction, P-Voxel < 0.005，P-Cluster < 0.05); and reduced in the right cerebellum (191 voxels, t = -6.487), the left middle temporal gyrus (140 voxels, t = -5.516), and the left precentral gyrus (119 voxels, t = -4.764) (GRF correction, P-Voxel < 0.005，P-Cluster < 0.05) in PSD group. ConclusionAutonomic nerve function is related to motor dysfunction in patients with PSD. The modulation of emotional, cognitive and motor brain regions by the autonomic nervous system may play a role in influencing the motor function in patients with PSD.
