A Clinical Study of the Therapeutic Effect of Clocortolone on soem Dermatoses.
- Author:
Jong Sung CHOI
;
Kwang Joong KIM
;
Jang Kyu PARK
;
Won Suk KIM
;
Yoo Shin LEE
- Publication Type:Original Article
- MeSH:
Animal Experimentation;
Dermatitis, Atopic;
Dermatitis, Contact;
Dermatology;
Eczema;
Humans;
Hydrocortisone;
Psoriasis;
Research Personnel;
Seoul;
Skin Diseases*
- From:Korean Journal of Dermatology
1977;15(4):437-441
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cloeortolone (9-a-chloro-6-a fluoro-11-B 21 digydroxy-16 methyl preganl,4-diene) is a newly synthesized corticonsteroid which has been found to have potent antinflammatory action and good tolerance through animal experiment. Several investigators reported its therapeutic affect in various dermatoses by topical application. The present was undertaken to evaluate the therapeutic effect of 0.1% clocortolone cream (Purantix-Sandoz) in patients with eczematous dermatoses and with psoriasis and to compare its effect with that of I% hydrocortisone. Eleven patients with contact dermatitis, 10 with psoriasis entered this study durtin the period of 6 months from January to june, 1977 at the Department of Dermatology, Seoul National University Hospital. All patients were instructed to apply 0.1% Clocortolone cream on one side of their lesion and 1%hydrocortisone cream on the opposite site for two weeks. After wo weeks' period of observation the status of the lesion was evaluated clinically and the tesults were as follows. 1. Ninety one percent of patiens with contact dermatitis, 70% of atopic dermatitis, 60% of nenrodermatitis, 67% of nummular eczema and 60% of psoriasis responded very effectively or moderately effectively. The therapeutic responses were generally similar to that of 1% hydrocortisone. 2. During the ovservation period, there was no systemic of local side effect of 0.1% Clocortolone cream.
