Traditional Chinese Medicine Intervention in Acute Pancreatitis Based on TLR4 Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20241291
- VernacularTitle:基于TLR4信号通路探讨中医药干预急性胰腺炎研究进展
- Author:
Zuomei LUO
1
;
Yuqing WANG
1
;
Nan CHEN
1
;
Bingjie HAN
1
;
Liqun LI
2
;
Lijian LIU
2
;
Guangwen CHEN
2
;
Chengning YANG
2
Author Information
1. Graduate School of Guangxi University of Chinese Medicine，Nanning 530001，China
2. The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530001，China
- Publication Type:Journal Article
- Keywords:
acute pancreatitis;
traditional Chinese medicine;
Toll-like receptor 4（TLR4） signaling pathway;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(9):263-271
- CountryChina
- Language:Chinese
-
Abstract:
Acute pancreatitis （AP） is one of the most clinically common acute digestive disorders characterized by quick onset，rapid progression，severe condition，and high mortality. If the disease is not timely intervened in the early stage，it can develop into severe AP in the later stage，which damages the long-term quality of life and brings serious economic burden to patients and their families. However， the pathogenesis of this disease is complex and has not been fully explained. The generation and development of AP is closely related to many signaling pathways. Among them，Toll-like receptor 4（TLR4），as a transmembrane signal transduction receptor，can mediate immune response and inflammatory response，and play a key role in the occurrence and development of AP. Traditional Chinese medicine（TCM）can regulate the TLR4 signaling pathway with multiple targets，multiple effects，and multiple administration methods to inhibit inflammatory response，and effectively intervene in the progression of AP， which has gradually become a new craze for preventing and treating AP. Many studies have shown that TCM has obvious advantages in the prevention and treatment of AP. It can effectively treat AP by regulating TLR4 signaling pathway，strengthening immune resistance and defense，and inhibiting inflammatory response. Despite of the research progress，there is still a lack of comprehensive review on TCM regulation of TLR4 signaling pathway in the treatment of AP. Therefore，the literature on TCM regulation of TLR4 signaling pathway published in recent years was systematically reviewed and elaborated，aiming to provide new ideas for the treatment of AP and further drug development.
