Active Ingredients of Chinese Medicines Induce Ferroptosis in Tumor Cells： A Review
10.13422/j.cnki.syfjx.20232121
- VernacularTitle:中药活性成分诱导肿瘤细胞铁死亡的研究进展
- Author:
Huizhong ZHANG
1
;
Yibo ZHANG
1
;
Jing FU
2
;
Huating HUANG
1
;
Yidan RUAN
1
;
Xingbin YIN
1
;
Changhai QU
1
;
Jian NI
1
;
Xiaoxu DONG
1
Author Information
1. School of Chinese Materia Medica， Beijing University of Chinese Medicine， Beijing 102488， China
2. Beijing Hospital of Traditional Chinese Medicine， Capital Medical University， Beijing Institute of Chinese Medicine， Beijing 100010， China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
active ingredients of Chinese medicines;
tumor cells;
iron metabolism;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(9):245-253
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis， a new form of programmed cell death different from apoptosis， necrosis， and autophagy， is closely associated with a variety of physiological and pathological processes. Iron-mediated accumulation of reactive oxygen species is the main inducement of ferroptosis， the mechanism of which is related to intracellular lipid metabolism， iron metabolism， and antioxidant defense pathways. Multiple signaling axes and regulators jointly regulate the occurrence and disruption of ferroptosis. Studies have demonstrated that ferroptosis regulates the growth and proliferation of tumor cells. Inducing ferroptosis in tumor cells can control the growth， metastasis， and multi-drug resistance of tumors. Therefore， the effect and mechanism of ferroptosis on tumor cells have become a hot topic in anti-cancer research. As the research advances， a variety of ferroptosis inducers has been used in the clinical chemotherapy for cancers and demonstrate significant efficacy. Accordingly， the development of ferroptosis-inducing anticancer drugs has become a new research direction for tumor treatment. Some active ingredients such as lycorine， oleanolic acid， dihydroartemisinin， pseudolaric acid B， and ophiopogonin B of Chinese medicines can induce ferroptosis in tumor cells via lipid metabolism， iron metabolism， system Xc-， and GPX4/GSH to regulate the development of tumors， demonstrating a promising prospect in clinical treatment. Based on the theory of the mechanism of ferroptosis， this paper reviews the research progress in ferroptosis induced by active ingredients of Chinese medicines in tumor cells and describes the metabolic regulatory network of ferroptosis from signaling pathways and regulatory factors， providing new strategies for applying active ingredients of Chinese medicines in the treatment of tumors.
