Mechanism of miRNA Intervention in Osteoporosis and Intervention Effect of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20232342
- VernacularTitle:miRNA干预骨质疏松的机制及中医药干预作用研究进展
- Author:
Mingyue NIU
1
;
Wantao DONG
1
;
Shiming QIU
1
;
Jingyi LIU
1
;
Peng YUAN
1
;
Yanlong GONG
2
;
Xinxin LI
1
;
Zhangkai ZHAO
1
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Affiliated Hospital of Gansu University of Chinese Medicine， Lanzhou 730000， China
- Publication Type:Journal Article
- Keywords:
osteoporosis;
microRNA （miRNA）;
traditional Chinese medicine;
osteogenic differentiation;
osteoclastic differentiation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(9):228-235
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis （OP） is a skeletal metabolic disease characterized by bone loss and destruction of bone microstructure. Changes in estrogen levels are not the only pathogenic factors for the occurrence and development of OP. MicroRNA （miRNA） plays an important regulatory role in cells. The complementary sequences of miRNA and targeted mRNA combine to inhibit the expression of targeted mRNA through post-transcriptional regulation， forming a complex regulatory network. Research suggests that miRNA is closely related to the occurrence and development of various diseases， including inflammatory diseases， metabolic diseases， and cancer. Targeted mRNA participates in post-transcriptional gene expression regulation in OP， mainly regulating the balance among bone construction， bone resorption， and osteoblast differentiation. Therefore， miRNA-based gene therapy is a rapidly developing disease treatment strategy. Traditional Chinese medicine can improve bone metabolism by intervening in miRNA differential expression to target and regulate osteogenic/osteoclast differentiation. This article summarized the targeting effects of miRNAs in physiological and developmental processes such as bone cell proliferation， differentiation， survival， and apoptosis， reviewed and classified their mechanisms of action and targets， and sorted out the current treatment methods of traditional Chinese medicine for preventing and treating OP and drugs that exert bone protective functions through miRNAs. This review is expected to provide theoretical reference and research guidance for future research on OP treatment by regulating miRNA.
