Evaluation of Animal Model of Autism Spectrum Disorders Based on Characteristics of Clinical Symptoms of Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20240362
- VernacularTitle:基于中西医临床病证特点的孤独症谱系障碍动物模型评价
- Author:
Yatong ZHANG
1
;
Shuyi ZHAO
1
;
Libin YANG
1
;
Shan JIANG
1
;
Jiaxin SUN
1
;
Ping RONG
1
Author Information
1. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion，First Teaching Hospital of Tianjin University of Traditional Chinese Medicine，Tianjin 300381，China
- Publication Type:Journal Article
- Keywords:
autism spectrum disorder;
syndrome characteristics;
model evaluation;
integrating traditional Chinese and western medicine;
behavior;
neuroligin 4（NLGN4）;
contactin associated protein like 2（CNTNAP2）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(9):202-210
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveBased on the new method of animal model evaluation， this paper summarized and analyzed the characteristics of traditional Chinese medicine（TCM） and Western medicine syndromes in existing autism spectrum disorder（ASD） animal models， and put forward suggestions for improvement. MethodRelevant literature on ASD animal models in China National Knowledge Infrastructure（CNKI） and PubMed were searched. According to the diagnostic standards of traditional Chinese and western medicine， core symptoms and accompanying symptoms were assigned values， and the clinical consistency of the models was comprehensively evaluated. ResultMost ASD model experimental animals were rodents， and the modeling methods included genetic and non-genetic. Domestic research focused on biochemical induction， while foreign research used genetic models more commonly. Among all models， valproic acid induction had the highest clinical consistency， followed by the neuroligin 4（NLGN4） and contactin associated protein like 2（CNTNAP2） gene knockout models. Most modeling methods could meet the characteristics of surface validity and structural validity， but did not clearly distinguish TCM syndromes. Currently， there is no model that has a high degree of clinical agreement between TCM and western medicine at the same time. ConclusionThe existing ASD animal models are mostly constructed under the guidance of western medicine， which lacks the characteristics of TCM syndromes. And the selection of evaluation indicators of western medicine is relatively single， without specifying the types of TCM syndromes. It is recommended to apply TCM intervention factors during the process of model preparation， to improve the evaluation indicators of traditional Chinese and western medicine， and to emphasize the study of on non-human primates， so as to lay a solid foundation for future experiments.
