Biological Connotation of Disease-stage-state of Hypertension in Concept of State-target Differentiation and Treatment From Perspective of Lipophagy
10.13422/j.cnki.syfjx.20241293
- VernacularTitle:基于脂噬角度探讨“态靶辨治”理念下高血压病“病-期-态”的生物学内涵
- Author:
Zongyu WANG
1
;
Tingjun NONG
1
;
Jinghui ZHENG
1
Author Information
1. Guangxi University of Chinese Medicine，Nanning 530200，China
- Publication Type:Journal Article
- Keywords:
state-target;
lipophagy;
hypertension;
disease-stage-state;
biological connotation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(9):193-201
- CountryChina
- Language:Chinese
-
Abstract:
Hypertension is a common chronic disease with elevated arterial pressure as the main clinical manifestation，which can cause lesions in important organs such as heart，brain and kidney. In recent years，the prevalence of hypertension has increased，and its incidence is also increasing year by year. Combining the theory of traditional Chinese medicine （TCM） with personal clinical experience，Academician TONG Xiaolin put forward the specific pathogenesis of "disease-stage-state" of hypertension based on the state-target theory. Lipophagy plays an important role in the pathogenesis of hypertension by interfering with lipid metabolism，atherosclerosis，arterial plaque formation，vascular remodeling，vascular endothelial injury and other aspects of hypertension. Through modern medical and biological research，on the one hand，it is believed that the dynamic pathological changes in lipophagy are closely related to the "stage" of hypertensive state-target differentiation and treatment，corresponding to the time points of disease occurrence and development in the three stages of hypertension. On the other hand，it is believed that lipophagy is an important microscopic manifestation of the "state" of hypertensive state-target differentiation and treatment. From the perspective of lipophagy，this paper discusses the biological connotation of the 'disease-stage-state' model of state-target differentiation and treatment of hypertension and draws on the modern medicine to understand the law of disease development，matching the macro differentiation and treatment of TCM and the micro physico-chemical indicators of modern medicine to achieve precise TCM treatment. This study provides new ideas for the early prevention and treatment of hypertension and its complications.
