Research progress on metabolic activation of indirect carcinogens by CYP1A1
10.20001/j.issn.2095-2619.20231021
- VernacularTitle:CYP1A1与间接致癌物代谢活化作用的研究进展
- Author:
Huanhuan WANG
1
;
Yao WU
;
Huanwen TANG
;
Yuting CHEN
Author Information
1. School of Public Health, Guangdong Medical University, Dongguan, Guangdong 523808, China
- Publication Type:Review
- Keywords:
Cytochrome P450 enzyme;
CYP1A1;
Indirect carcinogens;
Metabolic activation;
Carcinogenesis;
Research progress
- From:
China Occupational Medicine
2023;50(5):596-600
- CountryChina
- Language:Chinese
-
Abstract:
Cytochrome P450 enzyme 1A1 (CYP 1A1) is one of the main members of CYP1A subfamily, which participates in metabolizing and activating a variety of indirect carcinogens. CYP1A1 can induce carcinogenesis by participating in activating exogenous compounds to produce intermediates or active metabolites that bind to specific biomolecules. CYP1A1 plays a critical role in the metabolic activation of benzo(a)pyrene e ［B(a)P］, and plays a key role in activating the toxic and carcinogenic effects of B(a)P. CYP1A1 involves in the metabolic activation of 7,12-dimethyl benzanthracene and 2-amino-1-methyl-6-phenylimidazo［4,5-b］pyridine (PhIP), and plays an important role in PhIP-induced genotoxicity. CYP1A1 is the main enzyme to metabolize and activate 7H-dibenzo［c,g］carbazole (DBC), a key factor in the carcinogenic effect of DBC. CYP1A1 is also associated with metabolic activation of indirect carcinogens such as aflatoxin B1, 3-nitrobenzene, and naphthalene. Inhibition of the catalytic activity of CYP1A1 can decrease the CYP1A1-mediated activity of carcinogens, thus playing a role in the prevention and treatment of malignant tumors.
