Association between congenital hypothyroidism and in-hospital adverse outcomes in very low birth weight infants.
10.3760/cma.j.cn112140-20231012-00281
- Author:
Sha ZHU
1
;
Jing XU
2
;
Ran Ran SHI
1
;
Xiao Kang WANG
1
;
Mao Mao SUN
1
;
Shi Na LI
3
;
Ling Ling GAO
4
;
Yuan Yuan LI
5
;
Hui Min WEN
6
;
Chang Liang ZHAO
7
;
Shuai LI
8
;
Juan JI
9
;
Cui Hong YANG
1
;
Yong Hui YU
1
Author Information
1. Department of Neonatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250014, China.
2. Department of Neonatology, Affiliated Hospital of Jining Medical University, Jining 272000, China.
3. Department of Neonatology, Yantai Yuhuangding Hospital, Yantai 264000, China.
4. Department of Neonatology, Liaocheng People's Hospital, Liaocheng 252000, China.
5. Department of Neonatology, W.F. Maternal and Child Health Hospital, Weifang 261000, China.
6. Department of Neonatology, Hebei PetroChina Central Hospital, Langfang 065000, China.
7. Department of Neonatology, the Third Hospital of Baogang Group, Baotou 014010, China.
8. Department of Neonatology, the First Affiliated Hospital of Shandong First Medical University, Jinan 250014, China.
9. Department of Neonatology, Feixian People's Hospital, Linyi 273400, China.
- Collective Name:Sino-Northern Neonatal Network Collaborative Group
- Publication Type:Journal Article
- MeSH:
Infant;
Male;
Infant, Newborn;
Humans;
Female;
Prospective Studies;
Congenital Hypothyroidism/epidemiology*;
Risk Factors;
Infant, Very Low Birth Weight;
Birth Weight;
Gestational Age;
Retinopathy of Prematurity/epidemiology*;
Infant, Newborn, Diseases;
Hospitals
- From:
Chinese Journal of Pediatrics
2024;62(1):29-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the association between congenital hypothyroidism (CH) and the adverse outcomes during hospitalization in very low birth weight infants (VLBWI). Methods: This prospective, multicenter observational cohort study was conducted based on the data from the Sino-northern Neonatal Network (SNN). Data of 5 818 VLBWI with birth weight <1 500 g and gestational age between 24-<37 weeks that were admitted to the 37 neonatal intensive care units from January 1st, 2019 to December 31st, 2022 were collected and analyzed. Thyroid function was first screened at 7 to 10 days after birth, followed by weekly tests within the first 4 weeks, and retested at 36 weeks of corrected gestational age or before discharge. The VLBWI were assigned to the CH group or non-CH group. Chi-square test, Fisher exact probability method, Wilcoxon rank sum test, univariate and multivariate Logistic regression were used to analyze the relationship between CH and poor prognosis during hospitalization in VLBWI. Results: A total of 5 818 eligible VLBWI were enrolled, with 2 982 (51.3%) males and the gestational age of 30 (29, 31) weeks. The incidence of CH was 5.5% (319 VLBWI). Among the CH group, only 121 VLBWI (37.9%) were diagnosed at the first screening. Univariate Logistic regression analysis showed that CH was associated with increased incidence of extrauterine growth retardation (EUGR) (OR=1.31(1.04-1.64), P<0.05) and retinopathy of prematurity (ROP) of stage Ⅲ and above (OR=1.74(1.11-2.75), P<0.05). However, multivariate Logistic regression analysis showed no significant correlation between CH and EUGR, moderate to severe bronchopulmonary dysplasia, grade Ⅲ to Ⅳ intraventricular hemorrhage, neonatal necrotizing enterocolitis in stage Ⅱ or above, and ROP in stage Ⅲ or above (OR=1.04 (0.81-1.33), 0.79 (0.54-1.15), 1.15 (0.58-2.26), 1.43 (0.81-2.53), 1.12 (0.70-1.80), all P>0.05). Conclusion: There is no significant correlation between CH and in-hospital adverse outcomes, possibly due to timely diagnosis and active replacement therapy.
