Research advances in neutrophil extracellular traps and liver diseases
- VernacularTitle:中性粒细胞胞外诱捕网（NET）与肝脏疾病的关系
- Author:
Zhuoga RENZENG
1
;
Kangjie YANG
2
;
Yongliang LU
2
;
Zhixin WANG
1
;
Haijiu WANG
1
Author Information
- Publication Type:Review
- Keywords: Extracellular Traps; Liver Diseases; Liver Neoplasms
- From: Journal of Clinical Hepatology 2024;40(3):639-643
- CountryChina
- Language:Chinese
- Abstract: Neutrophils play an immune defense role by releasing the proteases such as neutrophil elastase and myeloperoxidase to form neutrophil extracellular trap （NET） and participate in the inflammatory response of various liver diseases， but the excessive release of NET may worsen liver tissue damage and has thus become one of the risk factors for liver diseases. In recent years， studies have shown that the excessive release of NET can promote the progression of liver diseases （such as viral hepatitis， nonalcoholic steatohepatitis， and hepatic ischemia-reperfusion injury） to liver cancer， and clarifying the mechanism of action of NET is of great importance for the diagnosis and progression of liver diseases. Therefore， this article elaborates on the latest research advances in NET in liver diseases， so as to provide new insights into the diagnosis and treatment of liver diseases and the prevention of liver cancer.
