Role of mesenchymal stem cells and their exosomes in the treatment of drug-induced liver injury

VernacularTitle:间充质干细胞及其外泌体在药物性肝损伤治疗中的作用
Author: Guojing XING ¹ ; Longlong LUO ¹ ; Lifei WANG ¹ ; Shunna WANG ¹ ; Xiaofeng ZHENG ² ; Lixia LU ¹ ; Jiucong ZHANG ¹
Author Information

1. Department of Gastroenterology， The 940th Hospital of Joint Logistic Support Force of PLA， Lanzhou 730050， China
2. Department of Gastroenterology， The Second Hospital of Lanzhou University， Lanzhou 730030， China
Publication Type:Review
Keywords: Mesenchymal Stem Cells; Exosomes; Drug Induced Liver Injury
From: Journal of Clinical Hepatology 2024;40(3):633-638
CountryChina
Language:Chinese
Abstract: The incidence rate of drug-induced liver injury （DILI） is increasing year by year with unknown mechanisms， and the treatment methods for DILI mainly include drugs， liver support systems， and liver transplantation， all of which have certain limitations. Therefore， the search for safer and more effective treatment methods has become a research hotspot at present. Studies have shown that mesenchymal stem cells and their exosomes can alleviate liver injury by reducing liver inflammation， promoting hepatocyte proliferation and regeneration， inhibiting the apoptosis of hepatocytes， improving oxidative stress， and regulating immunity. This article briefly reviews the role of mesenchymal stem cells and their exosomes in the treatment of DILI， so as to provide a reference for further research.