Mechanism of action of Polygonum multiflorum in inducing liver injury： A study based on signaling pathways

Zihan Liang; Jiahui LI; Shuang Cheng; Zhuoya Yuan; Wenya Rong; Yajie Liu; Yujie Hao; Ruilin Wang

Return

Mechanism of action of Polygonum multiflorum in inducing liver injury： A study based on signaling pathways

VernacularTitle:何首乌致肝损伤的信号通路及其作用机制
Author: Zihan LIANG ¹ ; Jiahui LI ¹ ; Shuang CHENG ¹ ; Zhuoya YUAN ¹ ; Wenya RONG ² ; Yajie LIU ¹ ; Yujie HAO ¹ ; Ruilin WANG ³
Author Information

1. First Clinical Medical College of Henan University of Chinese Medicine， Zhengzhou 450000， China
2. School of Traditional Chinese Medicine， Southern Medical University， Guangzhou 510405， China
3. Department of Traditional Chinese Medicine Hepatology， The Fifth Medical Center of PLA General Hospital， Beijing 100039， China
Publication Type:Review
Keywords: Polygoni Multiflori Radix; Chemical and Drug Induced Liver Injury; Signal Transduction
From: Journal of Clinical Hepatology 2024;40(3):626-632
CountryChina
Language:Chinese
Abstract: Polygonum multiflorum （PM）， a commonly used Chinese herbal medicine in clinical practice， has been associated with frequent reports of liver injury in recent years， and the medication safety of PM has attracted more and more attention in China and globally. This article reviews the recent research advances in the signaling pathways and mechanisms of PM in causing drug-induced liver injury （DILI） and aims to provide new ideas for the proper and rational use of PM in clinical practice. The results show that PM is involved in the regulation of various signaling pathways， and it leads to the death of hepatocytes by destroying mitochondrial function， exacerbating bile acid accumulation， and inducing immune response， oxidative stress， and endoplasmic reticulum stress， thereby inducing the development and progression of DILI through multiple targets， pathways， and levels.