Diagnosis and treatment principles of liver injury induced by antithyroid drugs
- VernacularTitle:抗甲状腺药物所致肝损伤的诊断与治疗原则
- Author:
Ruitao YANG
1
;
Rui YANG
2
;
Xun DENG
3
;
Senxiang ZENG
1
;
Xiaoyan YANG
2
Author Information
- Publication Type:Review
- Keywords: Drug Induced Liver Injury; Methimazole; Propythiouracil; Hyperthyroidism
- From: Journal of Clinical Hepatology 2024;40(3):621-625
- CountryChina
- Language:Chinese
- Abstract: Pharmacotherapy is the primary treatment method for hyperthyroidism. Antithyroid drugs can induce liver injury， and the diagnosis of drug-induced liver injury is mostly exclusive based on medical history collection， clinical symptoms， serum biochemistry， radiological examination， and histology. According to the severity of liver injury， drug-induced liver injury can be classified into mild， moderate， severe， and fatal degrees. Drug withdrawal may not be necessary for patients with mild liver injury， but regular monitoring of liver function is required； in severe cases， patients may develop liver failure， which may lead to a mortality rate， and early identification， timely drug withdrawal， and reasonable pharmacotherapy can help to avoid fatal consequences. The treatment principles of liver injury induced by antithyroid drugs include promoting the recovery of liver injury， preventing the severe exacerbation and chronicity of liver injury， and reducing the risk of death. Standardized medication， timely monitoring， early identification， and early treatment are important measures for the prevention and treatment of liver injury induced by antithyroid drugs.
