Re-understanding of the mechanism of coagulation disorder in liver cirrhosis

VernacularTitle:肝硬化凝血障碍机制的再认识
Author: Rongrong SUN ¹ ; Na HE ¹ ; Fenna ZHANG ¹ ; Xinyi ZHANG ² ; Ziyi WANG ² ; Hui WANG ² ; Nana BIAN ² ; Honglin YAN ¹
Author Information

1. Department of Gastroenterology， The First Affiliated Hospital of Xi’an Medical College， Xi’an 710077， China
2. Graduate School of Xi’an Medical University， Xi’an 710021， China
Publication Type:Review
Keywords: Liver Cirrhosis; Blood Coagulation; Haemorrhage; Thrombosis
From: Journal of Clinical Hepatology 2024;40(3):616-620
CountryChina
Language:Chinese
Abstract: The liver plays an important regulatory role in maintaining the dynamic balance of coagulation and anticoagulation in the body. Such dynamic balance is fragile in patients with liver cirrhosis， and the risk of bleeding can be increased due to reductions in coagulation factors and platelet count and excessive fibrinolysis； meanwhile， thrombus can be formed due to the increases in von Willebrand factor and coagulation factor Ⅷ， the reductions in anticoagulant protein C and anticoagulant protein S， the increase in thrombin-generating potential， and alterations in antifibrinolytic components. This article reviews the mechanisms of coagulation disorder in liver cirrhosis， so as to help clinicians with the prevention and treatment of bleeding or thrombotic disorders in patients with liver cirrhosis.