Regulatory effect and mechanism of macrophage polarization in liver fibrosis

VernacularTitle:巨噬细胞极化在肝纤维化中的调控作用机制
Author: Xiaoyang BAI ¹ ; Xu ZHANG ² ; Long HAI ¹ ; Xiangchun DING ¹
Author Information

1. Department of Infectious Diseases， Academy of Medical Sciences， General Hospital of Ningxia Medical University， Yinchuan 750000， China
2. Department of Surgery， Academy of Medical Sciences， General Hospital of Ningxia Medical University， Yinchuan 750000， China
Publication Type:Review
Keywords: Liver Fibrosis; Macrophages; Cell Polarization
From: Journal of Clinical Hepatology 2024;40(3):611-615
CountryChina
Language:Chinese
Abstract: Liver fibrosis is the healing reaction of chronic liver injury caused by various factors such as viral infection， alcohol， and chemical substances and is a key link in the progression of chronic liver diseases to liver cirrhosis and liver cancer. Liver macrophages are considered important mediators of liver injury and repair， and the polarization trend of macrophages has a bidirectional regulatory effect on liver fibrosis. This article reviews the role of different phenotypes of liver macrophages in the development and progression of liver fibrosis， in order to provide new ideas for the prevention and treatment of fibrosis.