Application of Mendelian randomization analysis in exploring the etiology of nonalcoholic fatty liver disease

VernacularTitle:孟德尔随机化分析方法在非酒精性脂肪性肝病病因探索中的应用
Author: Ziwei GUO ¹ ; Qingjuan WU ¹ ; Yongan YE ² ; Lanyu CHEN ¹ ; Wenliang LYU ¹
Author Information

1. Department of Infectious Diseases， Guang’anmen Hospital， Chinese Academy of Chinese Medical Sciences， Beijing 100053， China
2. Department of Spleen and Stomach， Dongzhimen Hospital， Beijing University of Chinese Medicine， Beijing 100700， China
Publication Type:Review
Keywords: Non-alcoholic Fatty Liver Disease; Mendelian Randomization Analysis; Causality; Instrumental Variables
From: Journal of Clinical Hepatology 2024;40(3):589-593
CountryChina
Language:Chinese
Abstract: Nonalcoholic fatty liver disease （NAFLD） is an abnormal lipid metabolic disorder of the liver characterized by accumulation of a large amount of lipids in the liver， and it is currently the most common liver disease around the world. Mendelian randomization （MR） incorporates genomic data into traditional epidemiological study designs to infer the causal relationship between exposure factors and disease risk. In recent years， MR has been widely used in studies on inference of the etiology of NAFLD. This article systematically summarizes the advances in the application of MR in NAFLD research， so as to provide new ideas for understanding the nature of the disease and scientific interventions.