Research progress of traditional Chinese medicine regulating related signaling pathways to promote tendon-bone healing
- VernacularTitle:中药调控相关信号通路促进腱骨愈合的研究进展
- Author:
Chaoqiang YANG
1
;
Xiaomin WANG
2
;
Liang WANG
3
;
Yican WANG
1
;
Tiantai KANG
1
;
Qing YANG
1
;
Hongxu SHU
1
;
Yunyun YANG
1
;
Hulin ZHANG
2
Author Information
1. Clinical College of Traditional Chinese Medicine，Gansu University of Traditional Chinese Medicine，Lanzhou 730030，China
2. Dept. of Orthopaedics，North Branch of Affiliated Hospital of Gansu University of Chinese Medicine，Lanzhou 730030，China
3. Dept. of Orthopaedics，Gansu Provincial Central Hospital，Lanzhou 730070，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
tendon-bone healing;
signal pathway;
mechanism of action
- From:
China Pharmacy
2024;35(6):767-772
- CountryChina
- Language:Chinese
-
Abstract:
Tendon-bone healing is a complex biological process. Multiple signaling pathways are involved in tendon-bone healing， including transforming growth factor-β signaling pathway， bone morphogenetic protein signaling pathway， Wnt signaling pathway， fibroblast growth factor signaling pathway and nuclear transcription factor-κB signaling pathway. This paper summarizes the research status of traditional Chinese medicine regulating related signaling pathways to promote tendon-bone healing. It is found that a variety of traditional Chinese medicine monomers or herbal extracts （such as baicalein， icariin， total flavonoids of Drynaria fortunei， parthenolide， total saponins of Panax notoginseng， etc.） and traditional Chinese medicine compounds （such as Taohong siwu decoction， Liuwei dihuang pill， Xujin jiegu liquid， etc.） can promote bone formation， anti-inflammatory， anti-oxidation， by regulating the above signaling pathways， thereby effectively promoting tendon-bone healing.
